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Because of rapid advances in genome sequencing technology, we can finally see the source code for life: the complete genomic DNA sequences that specify development, regulation, and function of organisms. Our laboratory develops computational methods for genome sequence analysis. We are particularly interested in methods for identifying remote evolutionary relationships between distantly related protein and RNA sequences.
We're a Howard Hughes Medical Institute laboratory at Harvard University, in Molecular & Cellular Biology and in Applied Mathematics in Biolabs on the Cambridge campus. We're affiliated with the Harvard Data Science Initiative, the 安卓番羽土啬软件, and the Center for Brain Science.
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Remote Homology Search with Hidden Potts Models.
G. W. Wilburn, S. R. Eddy.
bioRxiv, and manuscript submitted, 2023.Supplementary material : [appendix on importance sampling] [code and data tarball]preprint -
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C. M. Weisman, A. W. Murray, S. R. Eddy.
bioRxiv, and manuscript submitted, 2023.Analysis server : [abSENSE]preprint
Download software : [github]
Supplementary material : [tar.gz tarball of suppl. tables (Excel)]
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If you're interested in doing a postdoc with us, contact me and propose a project idea. We usually have space and initial funding available.
Graduate students in the group come from many different Harvard programs, including MCO (Molecules, Cells, and Organisms), Systems Biology, Biophysics, Lantern专业版apk, and Physics.
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Department of Molecular & Cellular BiologyBiological Laboratories 1008A
16 Divinity Avenue
Harvard University
Cambridge MA 02138, USA
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Lantern专业版apk
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Infernal
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Pfam
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Rfam
The Rfam database of RNA alignments, consensus secondary structures, and profile SCFGs.
latern专业破解版安卓最新版
The Dfam database of repetitive DNA sequence elements.
sean@hvica3.wcbzw.com
Howard Hughes Medical Institute
